Hengkuan Li on Muck Rack

Hengkuan Li

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Articles

Cross-species insights into placental evolution and diseases at the single-cell resolution

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By Guanghui Tan, Ao Zhang, Jingyu Yang, Fei Wang, Tao Shi, Haoping Wang, Huiquan Shan, Jilong Ren, Yaqi Zhou, Menghan Wang, Funong Luo, Xi Guo, Wuqiang Huo, Yingran Liu, Zhannur Niyazbekova, Xihong Wang, Zhenyu Xiao, Yi Zheng, Yu Jiang, Xuesha Cao, Youjie Cui, Hengkuan Li
| Nature Verified
Abstract The placenta is essential for fetal development, yet its molecular evolution across mammals remains elusive. Here, we present a comprehensive single-cell transcriptomic atlas of ~300,000 cells from ten species representing the four primary placental types: discoid, cotyledonary, diffuse, and zonary. Our cross-species analysis identifies trophoblast lineages as the primary drivers of placental diversification.
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