Hengxu Mao on Muck Rack

Hengxu Mao

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Articles

In Situ Detection of α-Synuclein Seeding Activity Using Quiescent Seed Amplification Assay

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By Hengxu Mao, Yaoyun Kuang, Wei Dai, Hao Lin
| biorxiv.org
Abstract Accurate detection of α-synuclein (αSyn) seeding activity is crucial for understanding synucleinopathies like Parkinson's disease. Traditional seed amplification assays lack spatial resolution, while antibody-based methods only capture pre-formed aggregates. To overcome this limitation, we developed the Quiescent Seed Amplification Assay (QSAA), enabling the in situ amplification and visualization of αSyn seeding activity directly within tissue sections.
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Optimal Preservation of PFFs in Glycerol Enhances Suitability for Modeling Parkinson's Disease

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By Weiqing Huang, Tingting Gan, Hengxu Mao, Yaoyun Kuang
| Wiley Online Library Verified
Conflict of Interest The authors declare no conflict of interest. References 1, , Prion 2008, 2, 112. 2, , , , , , J. Am. Chem. Soc. 2007, 129, 5374. 3, Cold Spring Harbor Perspect. Biol. 2017, 9, a023572. 4, Chem. Sci. 2022, 13, 10177. 5, , , , , , , , Chem. Sci. 2024, 15, 2528. 6, , , , , , , Angew. Chem., Int. Ed. Engl. 2014, 53, 7799. 7, , , , Angew. Chem., Int. Ed. Engl. 2008, 47, 5046. 8, , Chem. Rev. 2018, 118, 1691. 9, , , , Pharmaceuticals (Basel) 2021, 14, 471. 10, , , , , , , , , , , J. Parkinsons Dis.
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