Henriët van Middendorp

Introduction Fibromyalgia is a complex disorder characterized by chronic, widespread nociplastic pain, with clinical features suggestive of central sensitization mechanisms.1 While its etiology remains largely unclear, systemic factors such as neuroinflammation, chronic stress, and autonomic dysregulation have been proposed to play significant roles.2 Despite its profound impact on quality of life, treatment options for fibromyalgia remain limited.