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Henrike Barbara Zech on Muck Rack

Henrike Barbara Zech

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Comparing and combining xevinapant with ATR and PARP inhibition for the radiosensitization of HPV-negative HNSCC cells - Scientific Reports

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By Fruzsina Gatzemeier, Sabrina Christiansen, Cordula Petersen, Kai Rothkamm, Christian S. Betz, Malte Kriegs, Thorsten Rieckmann, Julius Roehrle, Adriana Perugachi-Heinsohn, Henrike Barbara Zech
| Nature Verified
Abstract Radiochemotherapy with the apoptosis stimulator xevinapant demonstrated superiority over radiochemotherapy in a randomized phase 2 trial in head and neck squamous cell carcinoma (HNSCC) but the subsequent phase 3 trial failed. Here, we compared the radiosensitization through xevinapant with two other emerging approaches, the inhibition of ATR and PARP through tuvusertib and olaparib, in a panel of four radioresistant HPV-negative HNSCC cell lines (HSC4, UT-SCC-60A, SAS, SAT).
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