Henry Barrow

Article metrics loading... /content/journal/jgv/10.1099/jgv.0.002237 Metrics Download as PowerPoint /deliver/fulltext/jgv/107/3/jgv002237.html?itemId=/content/journal/jgv/10.1099/jgv.0.002237&mimeType=html&fmt=ahah References Matthews E, Beckham JD, Piquet AL, Tyler KL, Chauhan L et al. Herpesvirus-associated encephalitis: an update. Curr Trop Med Rep 2022; 9:92–100 [View Article] [Google Scholar] Jørgensen LK, Dalgaard LS, Østergaard LJ, Nørgaard M, Mogensen TH.

eLife Assessment This landmark manuscript comprehensively examines the roles of nine structural proteins in herpes simplex virus 1 (HSV-1) assembly and nuclear egress. By integrating cryo-light microscopy and soft X-ray tomography, the study presents an innovative approach to investigating viral assembly within cells. The research is thoroughly executed, yielding exceptional data that explain previously unknown functions expected to bear widespread influence.

Abstract Glycosphingolipids (GSLs) are crucial membrane components involved in essential cellular pathways. Complex GSLs, known as gangliosides, are synthesised in the ER/Golgi by a series of glycosyltransferase enzymes. Imbalances in GSL metabolism can lead to severe diseases, often affecting the nervous system. B4GALNT1 is a key enzyme in the ganglioside synthetic pathway, synthesising complex gangliosides including GM2 and GD2 from GM3 and GD3.