Henry Ng on Muck Rack

Henry Ng

As seen in: Nature, Science Magazine, Royal Society of Chemistry, The Architect's Newspaper, AHA/ASA Journals, Texas Medical Center, Bastille Post, Economic Digest
NB Med-Peds doc, foodie & queer health advocate. GLMA Past President. Professor. #BLM Opinions are my own. Ailurophile. Follow for more.🏳‍🌈 🔬🧬⚕🩺🇭🇰
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Articles

Phosphorylation by Aurora kinase A facilitates cortical-cytoplasmic dynamics of Par-3 in asymmetric division of radial glia progenitors

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By Jason Garcia, Vincent Mouilleau, Henry Ng, Xiang Zhao
| Science Magazine
Abstract During asymmetric cell division (ACD) of radial glia progenitors (RGPs), the cortical polarity regulator Par-3 is detected in the cytoplasm colocalizing with dynein and Notch ligand DeltaD (Dld). What drives Par-3 to the cytoplasm and its impact on RGP ACD remain unknown. Here, we visualize cytoplasmic Par-3 using in vivo time-lapse imaging and find that Ser954 of zebrafish Par-3 is phosphorylated by Aurora kinase A (AurkA) in vitro.
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Phosphate-binding pocket on cyclin B governs CDK substrate phosphorylation and mitotic timing - Nature Communications

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By Henry Ng
| Nature
Abstract Cell cycle progression is governed by complexes of the cyclin-dependent kinases (CDKs) and their regulatory subunits cyclin and Cks1. CDKs phosphorylate hundreds of substrates, often at multiple sites. Multisite phosphorylation depends on Cks1, which binds initial priming phosphorylation sites to promote secondary phosphorylation at other sites. Here, we describe a similar role for a recently discovered phosphate-binding pocket (PP) on B-type cyclins.
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"Patient Priorities-Aligned Care for Older Adults With Multiple Conditi" by Mary E Tinetti, Ardeshir Hashmi et al.

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By Mary E Tinetti, Ardeshir Hashmi, Henry Ng, Margaret Doyle
| Texas Medical Center
IMPORTANCE: Older adults with multiple conditions receive health care that may be burdensome, of uncertain benefit, and not focused on what matters to them. Identifying and aligning care with patients' health priorities may improve outcomes. OBJECTIVE: To assess the association of receiving patient priorities care (PPC) vs usual care (UC) with relevant clinical outcomes.
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