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Herbert Kim Lyerly on Muck Rack

Herbert Kim Lyerly

Chapel Hill
As seen in: Nature, Cancer Investigation
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Articles

Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd) - Nature Communications

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By Li-Chung Tsao, John Wang, Jason McBane, Ivan Spasojevic, Herbert Kim Lyerly, Xingru Ma
| Nature Verified
Abstract Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) targeting HER2, exhibiting significant clinical efficacy in breast cancer (BC) with varying HER2 expression, including HER2-low and HER2-ultralow. However, the precise mechanism underlying its efficacy and the contribution of immune activation in these settings remain unclear. Here, we demonstrate that T-DXd efficacy in HER2-low and HER2-negative BC is independent of HER2 engagement and ADC internalization.
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Self-replicating messenger RNA based cancer immunotherapy

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By Herbert Kim Lyerly, Lyerly HK
| ncbi.nlm.nih.gov
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Open in Who Shared View Duplicates (134) Issue with article?

Self-replicating messenger RNA based cancer immunotherapy - Cancer Gene Therapy

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By Herbert Kim Lyerly
| Nature Verified
In 1989, the Nobel Prize in chemistry was awarded to Thomas Cech for his findings that RNA in living cells not only act to encode information enabling the production of specific proteins from DNA, but its three-dimensional structure enables it to serve as a catalyst [1].
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