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Hernan Vargas Huerta on Muck Rack

Hernan Vargas Huerta

As seen in: BioRxiv, HowlRound
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Articles

Calcium (Ca2+) fluxes at Mitochondria-ER Contact Sites (MERCS) are a new target of senolysis in Therapy-Induced Senescence (TIS).

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By Hernan Vargas Huerta, Andrea Puebla-Huerta, Camila Quezada-Gutierrez, Pablo Morgado-Caceres
| BioRxiv
Abstract This study investigates the state of calcium (Ca2+) flux and Mitochondria-ER contact sites (MERCS) on Therapy-Induced Senescence (TIS). TIS cells-induced by Doxorubicin and Etoposide increase their MERCS contact surface but exhibit a decreased ER-mitochondria Ca2+ flux. TIS cells show decreased levels of IP3R isoforms and a decreased interaction between type 1 IP3R isoform and VDAC1. The ER-mitochondria Ca2+ flux is essential to maintain the viability of senescence cells.
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Action and Reaction / Acción Y Reacción

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By Felipe Pereira, Hernan Vargas Huerta
| HowlRound Verified
All citizens have to take charge of some injustice at the micro or macro level in society, and in Chile this is inextricably linked with centralization. We are a country that is just over 4000 kilometers long but with an average width of 177 kilometers, where fruit and other items continue to be exported from areas declared to be in drought, such as Petorca. From this situation, el campesino—the peasant—character is born, played by Hernán Vargas.
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