Hernando Gutierrez-Barbosa

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All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

4. Discussion The hu-NSG models described here exhibited an efficient xenograft development with an initial high expansion of human B cells relative to T cells (CD4+ CD8− and CD4− CD8+) in the peripheral blood, as previously reported []. However, comparing successful engraftment between studies is challenging, as it is influenced by various factors such as mouse strain, age, source of CD34+ cells engrafted, preconditioning method, and donor variability [,,,].