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Herodes Guzman

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Articles

Ruxolitinib prevents irreversible autoimmune endocrinopathies in APECED

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By Joseph Pechacek, Taura Webb, Rachel Wu, Princess Barber, Lindsey B. Rosen, Peter D. Burbelo, Benjamin Colton, Maria A. Sacta, Shana E. McCormack, Aaron Bennett, Kathleen M. Loomes, Neil Romberg, Niamh McGrath, Steven Holland, Theo Heller, Karen K. Winer, Stefania Pittaluga, Michail S Lionakis, Heather Moorman, Herodes Guzman
| Nature Verified
Abstract Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED/APS-1) is a monogenic disorder of failed central tolerance. Interferon-γ-driven inflammation in APECED underlies multiorgan autoimmunity and chronic mucocutaneous candidiasis and is targetable with JAK1/2 inhibition. Whether early cytokine blockade can avert irreversible endocrine failure is currently unknown.
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