Hervé M. Blottiere on Muck Rack

Hervé M. Blottiere

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Articles

Microbiome signature of Parkinson’s disease in healthy and genetically at-risk individuals

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By Elisa Menozzi, Yani Ren, Mallia Geiger, Jane Macnaughtan, Micol Avenali, Marco Toffoli, Marine Gilles, Rosaria Calabrese, Pierfrancesco Mitrotti, Luca Gallo, Alexandre Famechon, Roxana Mezabrovschi, Sofia Koletsi, Nadine Loefflad, Selen Yalkic, Naomi Limbachiya, Frederick Clasen, Suleyman Yildirim, Saeed Shoaie, Hervé M. Blottiere, Christian Morabito, Aymeric David, Benoit Quinquis, Nicolas Pons, Emmanuelle Le Chatelier, Franco Valzania, Francesco Cavallieri, Valentina Fioravanti, Giulia Toschi, Fabio Blandini, Mathieu Almeida, Stanislav Dusko Ehrlich, Victoria Meslier, Anthony H. V. Schapira
| Nature Verified
Abstract Parkinson’s disease (PD) is a major cause of disability. GBA1 variants are the most common genetic risk factor for PD and increase the risk up to 30-fold. Why only approximately 20% of GBA1 variant carriers develop PD remains unknown.
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A Consensus Statement on establishing causality, therapeutic applications and the use of preclinical models in microbiome research - Nature Reviews Gastroenterology & Hepatology

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By Amira Metwaly, Céline Druart, Paul Wilmes, Jens Walter, Stephan P. Rosshart, Mahesh S. Desai, Joël Doré, Hervé M. Blottiere, Emmanuelle Maguin, IHMCSA Consortium
| Nature Verified
Abstract The gut microbiome comprises trillions of microorganisms and profoundly influences human health by modulating metabolism, immune responses and neuronal functions. Disruption in gut microbiome composition is implicated in various inflammatory conditions, metabolic disorders and neurodegenerative diseases. However, determining the underlying mechanisms and establishing cause and effect is extremely difficult.
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Glutamate from the microbiome controls host metabolism - Nature Metabolism

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By Hervé M. Blottiere
| Nature Verified
In an attempt to investigate the role of enteroendocrine cells in the colon using elegant, targeted depletion tools, the authors of a study published in this issue of Nature Metabolism highlight the orexigenic role of a bacterial metabolite in the intestinal lumen, l-glutamate.
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