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Herwin Daub

As seen in: BioRxiv
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Articles

Elucidation of multiple high-resolution states of human MutSβ by cryo-EM reveals interplay between ATP/ADP binding and heteroduplex DNA recognition

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By Jung-Hoon Lee, Maren Thomsen, Herwin Daub, Gabriel Thieulin-Pardo
| BioRxiv
Abstract Human and mouse genetic studies have demonstrated a role for DNA mismatch repair (MMR) molecular machines in modulating the rate of somatic expansion of the huntingtin (HTT) CAG repeats, and onset and progression of Huntington′s Disease (HD). MutSβ, a key component of the MMR pathway, is a heterodimeric protein of MSH2 and MSH3 that recognizes and initiates the repair of extrahelical DNA extrusions.
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Conformational dynamics and DNA recognition by human MutSbeta

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By Jung-Hoon Lee, Maren Thomsen, Stefan Steinbacher, Herwin Daub
| BioRxiv
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