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Heshan Peiris

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Articles

Regulator of Calcineurin 1 helps coordinate whole‐body metabolism and thermogenesis

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By David Rotter, Heshan Peiris, D Bennett Grinsfelder, Alyce M Martin
| embor.embopress.org
Increasing non‐shivering thermogenesis (NST), which expends calories as heat rather than storing them as fat, is championed as an effective way to combat obesity and metabolic disease. Innate mechanisms constraining the capacity for NST present a fundamental limitation to this approach, yet are not well understood.
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Discovering human diabetes-risk gene function with genetics and physiological assays

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By Sangbin Park, Xueying Gu, Heshan Peiris, Shreya Louis
| Nature Verified
To assess T2D candidate risk gene function, we crossed gene-specific RNAi lines with tissue-specific driver lines to inactivate gene expression in Drosophila IPCs (functional orthologue of mammalian beta cells), and other insulin target tissues, like fat body (equivalent to vertebrate liver and fat).
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