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Abstract The contribution of the gut microbiome to chronic heart failure (HF) remains poorly defined. We performed integrated microbiome and host multi-omic profiling of adults with chronic systolic HF due to nonischemic cardiomyopathy (n = 59) and healthy participants (n = 50), including longitudinal sampling in some cases.
A.A.M. is currently an employee of Google, and A.D. is an employee of Calico Life Sciences. D.P. and T.M. are members of the scientific advisory board of January AI. M.P.S. is a co-founder and a member of the scientific advisory board of Personalis, Qbio, January AI, SensOmics, Protos, Mirvie, RTHM and Iollo. He is on the scientific advisory board of Danaher, Neuvivo and Jupiter. All other authors declare no financial or non-financial competing interests.
Supported by USDA National Institute of Food and Agriculture Agriculture and Food Research Initiative-Education and Literacy Initiative Predoctoral Fellowship 2016-67011-25174, NIH grant 1R03HD080824-01A1, Gerber Foundation grant 1843-3882, the American Egg Board, Egg Nutrition Center, and the Beef Checkoff through the National Cattlemen’s Beef Association and the Nebraska Beef Council.
Background: The impact of the reproductive state on vitamin D metabolism and requirements is uncertain in part because of a lack of studies with controlled dietary intakes of vitamin D and related nutrients. Objective: We aimed to quantify the impact of the reproductive state on a panel of vitamin D biomarkers among women of childbearing age consuming equivalent amounts of vitamin D and related nutrients.
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