Cell Host & Microbe

Keywords antimicrobial discovery antibiotics antimicrobial resistance machine learning artificial intelligence Introduction The discovery and clinical application of antimicrobials revolutionized modern medicine throughout the 1940s and beyond.

Keywords Engraftment auxotrophy kill switches Quorum sensing calprotectin curli fibers porphyrin memory circuits CRISPR-associated transposases horizontal gene transfer Escherichia coli Nissle 1917 mucosal delivery Get full text access Log in, subscribe or purchase for full access. References 1. Felgner, S. ∙ Kocijancic, D. ∙ Frahm, M. ... Bacteria in Cancer Therapy: Renaissance of an Old Concept Int. J. Microbiol. 2016; 2016, 8451728 2. Gordon, S. Remembering Metchnikoff in the time of COVID-19 J. Leukoc.

Keywords fecal microbiome transplantation microbiome microbiota Introduction The intricate relationship between the human host and its indigenous commensal populations, collectively termed the microbiome, impacts host metabolism,1 immunity,2 and a large variety of communicable and non-communicable diseases, ranging from neurodegenerative diseases (e.g., Parkinson’s disease [PD]) to cancer.1,3,4 One attractive feature of the microbiome and its host regulatory capacity is that, in contrast to...

Keywords gut microbiota Bacteroides fragilis intestinal barrier pantothenic acid vitamin B5 microbial metabolism metabolic syndrome pantothenate kinase obetisy CoA Get full text access Log in, subscribe or purchase for full access. References 1. Neeland, I.J. ∙ Lim, S. ∙ Tchernof, A. ... Metabolic syndrome Nat. Rev. Dis. Primers. 2024; 10, 77 2. Tilg, H. ∙ Zmora, N. ∙ Adolph, T.E. ... The intestinal microbiota fuelling metabolic inflammation Nat. Rev. Immunol. 2020; 20:40-54 3. Damms-Machado, A. ∙ Louis, S.

Keywords antimicrobial resistance evolution machine learning artificial intelligence narrow-spectrum therapy precision medicine Introduction Infectious diseases were among the first fields to translate the principles of personalized medicine into clinical practice through the tailored application of antimicrobials.

Keywords gut microbiome colorectal cancer CRC early-onset colorectal cancer tumor microbiome meta-analysis virulence factors Fusobacterium nucleatum machine learning microbiome-diet associations Introduction The human gut microbiome is increasingly recognized as an important factor in the initiation and progression of colorectal cancer (CRC).1,2,3,4 Microbiome surveys of stool and colon tissue have played a major role in defining polymicrobial signatures of CRC and guiding our understanding...

Preterm infant stool microbiota extraction Approximately 20 to 200 mg of stool is weighed and recorded. Fecal material is homogenized by resuspending with vigorous vortexing and pipetting in 1 mL phosphate buffered saline (PBS, pH 7.4) then pelleted by centrifugation (10 minutes, 9000g). Supernatant is collected and stored (-80°C) for testing fecal waters.

Keywords irritable bowel syndrome fatty acid ethanolamides oleoylethanolamide PPARα serotonin Eubacterium rectale visceral hypersensitivity insulin resistance disorder of gut-brain interactions enterochromaffin cells Get full text access Log in, subscribe or purchase for full access. References 1. Ford, A.C. ∙ Sperber, A.D. ∙ Corsetti, M. ... Irritable bowel syndrome Lancet. 2020; 396:1675-1688 2. Lembo, A. ∙ Sultan, S. ∙ Chang, L. ...

Keywords CBASS CapV anti-phage immunity cell viability Pseudomonas aeruginosa 3′,3′-cGAMP abortive infection Get full text access Log in, subscribe or purchase for full access. References 1. Li, Y. ∙ Slavik, K.M. ∙ Toyoda, H.C. ... cGLRs are a diverse family of pattern recognition receptors in innate immunity Cell. 2023; 186:3261-3276.e20 2. Slavik, K.M. ∙ Morehouse, B.R. ∙ Ragucci, A.E. ... cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila Nature. 2021; 597:109-113 3. Cai, H.

keyword citrus huanglongbing effector salicylic acid papain-like cysteine proteases immune peptide protein engineering Get full text access Log in, subscribe or purchase for full access. References 1. Gottwald, T.R. Current epidemiological understanding of citrus Huanglongbing Annu. Rev. Phytopathol. 2010; 48:119-139 2. Bové, J.M. Huanglongbing: A destructive, newly-emerging, century-old disease of citrus J. Plant Pathol. 2006; 88:7-37 3. Wang, N. ∙ Pierson, E.A. ∙ Setubal, J.C. ...