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Hideru Obinata

As seen in: Science Magazine, BioRxiv
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Articles

Branched-chain amino acid metabolism is a crucial modulator of cellular senescence

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By Kazuki Irie, Hideru Obinata, Shinya Honda, Yuma Aramaki
| BioRxiv
Abstract Cellular senescence is a complex stress response that results in the permanent arrest of cell proliferation. The accumulation of senescent cells occurs during aging in living organisms, and contributes to tissue dysfunction. Although there are growing lines of evidence that various metabolic changes occur in senescent cells, the link between cellular metabolism and senescence is not yet fully understood.
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CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function

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By Matthew L. Kleinjan, Irina Jilishitz, Bhairavi Swaminathan, Hideru Obinata
| Science Magazine Verified
S1P signaling CLICs into place The chloride intracellular channels CLIC1 and CLIC4 are implicated in vascular development, particularly in response to oxidative stress. Mao et al. found that these CLICs mediate the selective activation of small GTPases in response to the lipid second messenger S1P.
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