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Hillery F. Gray on Muck Rack

Hillery F. Gray

As seen in: BioRxiv
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Articles

Dysregulation of FicD AMPylation causes diabetes by disrupting pancreatic endocrine homeostasis

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By Amanda Casey, Naqi Zaidi, Hillery F. Gray, Hazel A. Fields
| BioRxiv
Abstract Bi-functional enzyme FicD regulates the endoplasmic reticulum chaperone BiP using AMPylation and deAMPylation during ER homeostasis and stress, respectively. Human FicD with an arginine-to-serine mutation disrupts FicD deAMPylation activity resulting in severe neonatal diabetes. We generated the FicDR371S mutation in mice to create a pre-clinical murine model for neonatal diabetes.
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