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Hinako Ago

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Articles

Foxp3 drives context-dependent epigenetic programs that define regulatory T cell molecular identity and function

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By Wenhui Li, Yuxi Wei, Mieke Metzemaekers, Hinako Ago, Ryuichi Murakami, Shotaro Funatsu, Marina Osaki, Akira Nakajima, Yoshinori Hasegawa, Ryoji Kawakami, Shimon Sakaguchi, Shohei Hori
| Science Magazine Verified
Editor’s summary Regulatory T (Treg) cells are key orchestrators of immunological tolerance and are controlled by the transcription factor Foxp3. However, whether Foxp3 expression alone is sufficient to confer full Treg cell identity remains unclear. Using adoptive transfer of Foxp3-transduced conventional T cells into lymphopenic mice, Wei et al.
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