Hiraku Tokuma on Muck Rack

Hiraku Tokuma

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Articles

VMAT2 Safeguards β-Cells Against Dopamine Cytotoxicity Under High-Fat Diet-Induced Stress

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By Daisuke Sakano, Yuki Sonoda, Fumiya Uefune, Hiraku Tokuma
| Diabetes Magazine Verified
Islet Studies Abstract Vesicular monoamine transporter 2 (VMAT2) uptakes cytoplasmic monoamines into vesicles for storage. VMAT2 plays a role in modulating insulin release by regulating dopamine levels in the pancreas, although the exact mechanism remains elusive. We found that VMAT2 expression in β-cells specifically increases under high blood glucose conditions.
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