Hiranyamaya Dash

Abstract Summary MotifPeeker benchmarks epigenomic datasets where no "gold standard" reference exists, using motif enrichment as a key metric. With minimal input, users can analyse their data in a single function and receive an intuitive HTML report. Availability and Implementation MotifPeeker is available on Bioconductor at <a href="https://bioconductor.org/packages/devel/bioc/html/MotifPeeker.html">https://bioconductor.org/packages/devel/bioc/html/MotifPeeker.html</a>.

Abstract Epigenomic profiling provides insights into the regulatory mechanisms that govern gene expression. At a fundamental level, these mechanisms are determined by proteins that bind the DNA or modify the chromatin. Techniques such as ChIP-seq and CUT&Tag have been instrumental in mapping the binding sites of such proteins across the genome. Recent advances have led to the development of TIP-seq, a highly sensitive method devised to increase the number of unique reads per sample.