Hiroyu Hatano on Muck Rack

Hiroyu Hatano

As seen in: Nature, PLOS Medicine
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Articles

Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV disease - Nature Communications

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By Alton Barbehenn, Vivian Pae, Sannidhi Sarvadhavabhatla, Michael J Peluso, Jeffrey Martin, Frederick M. Hecht, Stephanie Cohen, Susan Buchbinder, Timothy J. Henrich, Hiroyu Hatano, Steven Deeks, Sophia Donaire, Caroline Sheikhzadeh
| Nature Verified
Abstract Despite antiretroviral therapy (ART), HIV persists in latently-infected cells (the HIV reservoir) which decay slowly over time. Here, leveraging >500 longitudinal samples from 67 people living with HIV (PLWH) treated during acute infection, we developed a mathematical model to predict reservoir decay from peripheral CD4 + T cells.
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HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study

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By Oliver Bacon, Timothy J. Henrich, Hiroyu Hatano
| PLOS Medicine Verified
We report HIV relapse despite initiation of ART at one of the earliest stages of acute HIV infection possible. Near complete or complete loss of detectable HIV in blood and tissues did not lead to indefinite ART-free HIV remission. However, the small numbers of latently infected cells in individuals treated during hyperacute infection may be associated with prolonged ART-free remission.
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