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Hiyam Marzouqa

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Articles

Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

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By Shanshan Lian, Anastasia A Minervina, Satoshi Okada, Janet G. Markle, Elissa K. Deenick, Federico Mele, Dina Averbuch, Macarena Lagos, Mohammed Alzahrani, Saleh Al-Muhsen, Rabih Halwani, Cindy S. Ma, Natalie Wong Verified, Claire Soudais, Marcela Gonzalez, Marcela González, Ruben Martinez-Barricarte, Danielle T. Avery, Daniela Latorre, Caroline Deswarte, Fabienne Jabot-Hanin, Egídio Torrado, Hiyam Marzouqa, Jamal Shamma, Chizuru Okada
| Science Magazine Verified
A surprising immune twist for RORC Abstract Bi-allelic RORC mutations Complete RORγ and RORγT deficiency Broad immunological phenotype Abolished production of IL-17A/F Selective defect in IFN-γ production Impaired IFN-γ production by γδ T cells The patients’ CD4+CCR6+ αβ T cells produce little IFN-γ in response to BCG Conclusion ACKNOWLEDGMENTS Supplementary Material REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article...
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