Holger Müller on Muck Rack

Holger Müller

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Articles

Laser phase plate improves structure determination of small proteins by cryo-EM

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By Ke-Ting Shin, Justin Stewart, Petar Petrov, Jessie Zhang Verified, Jonathan Remis, Jeremy Axelrod, Hang Cheng, Eric Cooper, Ian Hicklin, Robert M Glaeser, Holger Müller, Shahar Sandhaus, Cooper Schnurr
| Science Magazine Verified
Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Abstract Phase plates can in principle overcome the poor image contrast in electron cryo–microscopy (cryo-EM) and the resulting limits on the structural reconstruction of small proteins. However, previous designs have been unstable and compromised the high-resolution signal. They have thus been unable to surpass results achieved by standard cryo-EM.
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Crossed laser phase plates for transmission electron microscopy

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By Petar Petrov, Jessie Zhang Verified, Jeremy Axelrod, Pavel K. Olshin, Holger Müller
| Nature Verified
Abstract A phase plate has long been sought in transmission electron microscopy (TEM) to maximize the image contrast of weakly-scattering objects like biomolecules. The laser phase plate (LPP) has recently demonstrated that an amplified, focused laser standing wave reliably phase shifts the electron beam, achieving phase-contrast TEM. Building on the single-beam LPP, here we introduce the crossed laser phase plate (XLPP): two laser standing waves which intersect in the diffraction plane.
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Mi-24-Kampfhubschrauber hautnah: Abschied vom "fliegenden Panzer"

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By Patrick Zwerger Verified, Patrick Hoeveler, Holger Müller
| FLUG REVUE Verified
Die Spannung in der vibrierenden Kabine unserer H145M ist mit Händen zu greifen. Ungeduldig blicken die Augenpaare der Fotografen nach draußen, scannen gebannt die Umgebung ab. Die Sonne scheint aus voller Kraft, der Himmel zeigt sich wolkenlos – was für ein Glück, denn gestern hat es noch geregnet. Unter uns zieht die grün-braune ungarische Tiefebene vorbei, vereinzelt sind Schneefelder zu sehen. Wir schreiben den 28. Januar 2026 – ein Tag, den niemand hier an Bord so schnell vergessen wird.
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