Skip To Main Content
Holly A. Gamlen on Muck Rack

Holly A. Gamlen

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Holly A.

Contact Holly A., search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

MEN1 mutations mediate clinical resistance to menin inhibition - Nature

|
By Daniela V. Wenge, Homa Rahnamoun, Richard Stone, Wenbin Xiao, Holly A. Gamlen, Aaron J. Stonestrom, Elizabeth T. Ener, John G. Doench, John Chodera, Eric S. Fischer, Ross Levine, Scott Armstrong
| Nature Verified
Abstract Chromatin-binding proteins are critical regulators of cell state in haematopoiesis1,2. Acute leukaemias driven by rearrangement of the mixed lineage leukaemia 1 gene (KMT2Ar) or mutation of the nucleophosmin gene (NPM1) require the chromatin adapter protein menin, encoded by the MEN1 gene, to sustain aberrant leukaemogenic gene expression programs3,4,5.
Open in Who Shared Issue with article?
See all 1 articles