Holly Holliday

Abstract Diffuse midline gliomas (DMG) are deadly pediatric brain cancers with limited treatment options. These tumors likely arise from oligodendrocyte precursor cells (OPC) that acquire a driver histone mutation, leading to an aberrant epigenome. RNA N6-methyladenosine (m6A) is a vital epi-transcriptomic modification that regulates RNA processes and plays a significant role in OPC development through its regulation of transcripts involved in histone modification processes.

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Editor’s summary Blood tests to monitor evolving brain injury in ischemic stroke could be a cost-effective and fast alternative to currently used noninvasive approaches such as MRI. Here, Vlegels et al. used a single-molecule detection assay on blood samples and found that brain-derived tau abundance was associated with the severity of brain injury in three cohorts of patients with ischemic stroke.