Holly Roach on Muck Rack

Holly Roach

Verified
London
As seen in: Professional Pensions, Nature, The Croydon Advertiser, BusinessGreen, Investment Week, Professional Adviser, Cover Magazine UK
Deputy Editor @ProfPensions Contact me: holly.roach@incisivemedia.com
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Articles

m6A and the NEXT complex direct Xist RNA turnover and X-inactivation dynamics - Nature Structural & Molecular Biology

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By Guifeng Wei, Mafalda Almeida, Holly Roach Verified, Tatyana B. Nesterova
| Nature Verified
Abstract X-chromosome inactivation (XCI) in mammals is orchestrated by the noncoding RNA X-inactive-specific transcript (Xist) that, together with specific interacting proteins, functions in cis to silence an entire X chromosome. Defined sites on Xist RNA carry the N6-methyladenosine (m6A) modification and perturbation of the m6A writer complex has been found to abrogate Xist-mediated gene silencing. However, the relative contribution of m6A and its mechanism of action remain unclear.
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DB funding - May 2021: Assumption changes lead PPF index to new highs

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By James Phillips, Hope William-Smith Verified, Holly Roach Verified
| nql-professionalpensions-redesign.kreatio.com
Viability of Croydon's property-backed pension structure to be assessed after further valuations The proposal to rescind a controversial decision to transfer residential property into Croydon’s pension fund so it could pay less in contributions will be deferred until more valuation information is available.
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