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Hongshen Qiu on Muck Rack

Hongshen Qiu

As seen in: Nature
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Articles

PAPOLA-mediated hyperactive polyadenylation promotes leukemogenesis and leukemia stem cell self-renewal through metabolic reprogramming

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By Siyao Guo, Yutong Zou, Canfeng Zhang, Hui Han, Yishan Li, Yucong Sun, Zhaoyu Wang, Wanrui Zhang, Jiang Zhang, Yuli Gan, Qiang Zhang, Siyi Zheng, Yan Zhu, Wange Lu, Yong Bao, Meng Zhao, Shuibin Lin, Jieyi Ma, Hongshen Qiu
| Nature Verified
Abstract Polyadenylation is essential for mRNA stability and translational efficiency. Although poly(A) tail length is dynamically regulated under physiological conditions, its dysregulation and functional importance in cancer remain poorly understood. Here, we identify widespread poly(A) tail elongation and aberrant upregulation of poly(A) polymerase alpha (PAPOLA) in acute myeloid leukemia (AML), with high PAPOLA expression associated with poor clinical outcomes.
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