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A Large‐Scale Retrospective Study of Serum Des‐Gamma‐Carboxy Prothrombin as a Diagnostic Marker of HCC: Effect of Liver Function on Specificity
1 Introduction Primary liver cancer (PLC) arises from hepatocytes or intrahepatic cholangiocytes, and hepatocellular carcinoma (HCC) derived from hepatocytes is the dominant type, accounting for 85%–90% of PLC [1]. Global statistics in 2020 indicated that 905,677 new cases of HCC were diagnosed, ranked as the second cancer-related death [2]. Up to 75% of HCC occurs in Asia, and China has nearly 50% of the total [3].
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