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Hongying Chao on Muck Rack

Hongying Chao

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Articles

SRSF2 mutations contribute to bone marrow immune microenvironment alterations

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By Wei Li, Yu Jiang, Shu Fan, Xiaoli Zhou, Haoran Xu, Jie Liu, Xueting Zhang, Judong Luo, Changrui Tao, Hongying Chao
| Nature Verified
Abstract Somatic SRSF2 mutations are early lesions in myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML), yet how they contribute disease remain unclear. In this study, we generated two murine models that have not yet developed overt MDS/CMML-like phenotypes: (i) a cell-derived xenograft (CDX) by tail-vein injection of stable BA/F3-KRASG12C-SRSF2P95H cells and (ii) a Vav1-Cre conditional knock-in mouse heterozygous for Srsf2P95H.
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