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Hongying Sha on Muck Rack

Hongying Sha

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CDK8 phosphorylates SOX2 to maintain stemness of pituitary adenoma - Oncogene

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By Yilin Xie, Zerui Wu, Chenxing Ji, Yichao Zhang, Zhen Ye, Nidan Qiao, Zengyi Ma, Zhengyuan Chen, Wenqiang He, Yao Zhao, Zhao Ye, Hongying Sha
| Nature Verified
Abstract Pituitary adenomas (PAs) are intracranial tumours with severe clinical complications and increased morbidity. Stem cell-like characteristics play a crucial role in the initiation and progression of PAs. In this study, we identified CDK8 as a critical regulator of stemness in PA tumorigenesis. Immunohistochemical analysis demonstrated that CDK8 expression is elevated in clinical PA samples and correlates significantly with Knosp grades, indicating its potential role in parasellar invasion.
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