Hoon Je Seong

Abstract The human skin microbiome is shaped by a complex interplay of host physiology, environmental exposure, and microbial interactions across domains of life. However, the relative contributions of host genetics and geography remain unresolved. Here, we present the first application of ultra–low coverage human genome imputation from skin metagenomic data, analysing 1,756 samples from multiple skin types and timepoints, with matched genotypes from 327 individuals across five countries.

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