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Hopke Alex

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Articles

Neutrophil swarming delays the growth of clusters of pathogenic fungi

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By Allison K. Scherer, Michael K Mansour, Hopke Alex, Samantha Kreuzburg
| Nature Verified
Abstract Neutrophils employ several mechanisms to restrict fungi, including the action of enzymes such as myeloperoxidase (MPO) or NADPH oxidase, and the release of neutrophil extracellular traps (NETs). Moreover, they cooperate, forming “swarms” to attack fungi that are larger than individual neutrophils. Here, we designed an assay for studying how these mechanisms work together and contribute to neutrophil's ability to contain clusters of live Candida.
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