Aaron Brooks

Getting your Trinity Audio player ready... By Aaron Brooks As we mark the anniversary of the June 1 terrorist attack on Pearl Street, I keep thinking about how easy it is for communities to move on before they have truly reckoned with what happened. I can’t. I was there. I stood on Pearl Street that day with friends. I watched an act of antisemitic terror unfold in the heart of our town.

Background On 12 March 2026, the UK government confirmed that important changes will be made to the National Security and Investment Act (NSIA) Notifiable Acquisition Regulations (NARs) and the scope of the NSIA mandatory notification regime. The changes follow the consultation that closed in October 2025 (see related Akin Alert here) and represent the first major developments since the NSIA came into force in January 2022.

Abstract Atypical protein kinase C (aPKC) is a major regulator of cell polarity. Acting in conjunction with Par6, Par3 and the small GTPase Cdc42, aPKC becomes asymmetrically localised and drives the polarisation of cells. aPKC activity is crucial for its own asymmetric localisation, suggesting a hitherto unknown feedback mechanism contributing to polarisation. Here we show in the C. elegans zygote that the feedback relies on aPKC phosphorylation of Cdc42 at serine 71.