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7SK -enriched exosomes suppress the cancer phenotypes in human lung cancer cells: insights from 2D and microfluidic 3D in vitro models
Abstract Lung cancer, being the top cause of global cancer-related mortality, calls for effective treatments. RN7SK (7SK) is a long non-coding RNA (lncRNA) that plays a significant role in the regulation of gene transcription and thereby controls essential cellular activities. Limited evidence supports the anticancer potential of 7SK, and its suppressive effects have not been tested against lung cancer.
Small RNA-directed epigenetic programming of embryonic stem cell cardiac differentiation
RNA-mediated transcriptional upregulation of Cdk9 and other loci had been reported previously upon microinjection of small size RNAs in fertilized eggs1,2,3. To investigate whether Cdk9 target mRNAs induce transcriptional variation in other cell types, mouse embryonic stem cells were analysed after electroporation of a 22-nt oligoribonucleotide with a nucleotide sequence identical to that of the Cdk9 mRNA in exon 7 (Cdk9-f, Table 1).
Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth
Citation: Ghanbarian H, Wagner N, Polo B, Baudouy D, Kiani J, Michiels J-F, et al. (2016) Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth. PLoS ONE 11(6): e0156953. doi:10.1371/journal.pone.0156953 Copyright: © 2016 Ghanbarian et al.
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