Hradini Konthalapalli

1 Introduction Cell division is the sequence of events enabling a cell to segregate an identical copy of the genetic material to two daughter cells (Figure 1). Broadly speaking, the chromosome segregation machinery must comprise at least two components: a motor and a sensor. The motor is provided by the mitotic spindle, a cytoskeletal structure made of microtubules that dock to each sister chromatid at the level of the kinetochore (reviewed in [1]).