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Hsiang Chang on Muck Rack

Hsiang Chang

As seen in: Nature
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Articles

Structural basis for calcium-stimulating pore formation of Vibrio α-hemolysin - Nature Communications

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By Meng-Chiao Ho, Hsiang Chang
| Nature Verified
Abstract Vibrio α-hemolysins (αHLs) are β-pore-forming toxins secreted by Vibrio pathogens, crucial for the facilitation of bacterial infections through host cell lysis. These toxins are produced as inactive precursors, requiring proteolytic maturation and membrane association for activation within host tissues.
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