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Hsien-Yin Kao on Muck Rack

Hsien-Yin Kao

As seen in: Nature
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Bone- and muscle-targeted adeno-associated viral vectors enable tissue-selective vitamin D receptor knockdown in mice

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By Julian Chu, Nicholas Norris, Josephine Yu, Dirk Grimm, Jenny E. Gunton, Alexandra K. O’Donohue, Hsien-Yin Kao, Lucinda R. Lee, Aaron Schindeler
| Nature Verified
Abstract Vitamin D receptor (VDR) regulates musculoskeletal biology, but its adult, tissue-specific roles are difficult to resolve with germline or conventional conditional knockouts. We developed recombinant adeno-associated viral vectors (rAAVs) to drive Cre recombinase selectively in bone or muscle and used them to delete Vdr postnatally in Vdrfl/fl mice.
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