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Hsing Hui Wang

As seen in: BioRxiv
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Articles

UTX Coordinates TCF1 and STAT3 to Control Progenitor CD8+ T cell Fate in Autoimmune Diabetes

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By Ho-Chung Chen, Hsing Hui Wang, Karl B. Shpargel, Lisa Kohn
| BioRxiv
Abstract Type 1 Diabetes Mellitus (T1D) is driven by chronic autoimmune destruction of pancreatic beta cells, primarily mediated by CD8+ progenitor T cells that replenish pathogenic effectors. However, the regulatory mechanisms guiding this progenitor-to-effector transition remain unclear. T1D susceptibility has been linked to an X chromosome region (Xp13-p11) containing UTX, an epigenetic regulator.
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