Huaigang Chen on Muck Rack

Huaigang Chen

As seen in: Nature, PLOS ONE
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Articles

NEAT1 drives SARS-CoV-2 N protein–induced inflammation, metabolic reprogramming, and mitochondria–ER stress crosstalk - Scientific Reports

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By Cheng Qing, Huaigang Chen, Shuying Huang, Jianguo Zhang, Shichao Zhang, Cheng Wang, Zhiguo Hu, Yuting Yang, Jia Zhou, Zhenguo Zeng, Chaoqi Zhou, Kaihang Luo
| Nature Verified
Abstract SARS-CoV-2 remains a global health concern. Although its nucleocapsid (N) protein supports viral replication and evades host immunity, its role in host metabolic reprogramming and organelle homeostasis is not fully understood. This study aims to elucidate whether the N protein modulates glycolysis and mitochondrial-ER stress crosstalk via the long non-coding RNA NEAT1. We established human bronchial epithelial (HBE) cells stably expressing the N protein.
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Diagnostic efficacy of the optical flow ratio in patients with coronary heart disease: A meta-analysis

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By Jiangxi Province, Yanyan Xiao, Hong Wang, Huaigang Chen
| PLOS ONE
Loading metrics Open Access Peer-reviewed Research Article Abstract Background Coronary atherosclerotic heart disease (CAD) remains one of the most serious diseases threatening human health and life. PCI (Percutaneous Coronary Intervention) is the most common treatment for patients with CAD. A rigorous and comprehensive assessment of coronary artery lesions is now needed before PCI, however, there is no consensus on how best evaluate the combination of various intracavitary imaging techniques.
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