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The impact of EmrA deficiency on antibiotic-susceptibility and virulence- and stone-associated phenotypes in Proteus mirabilis
Abstract Background: Proteus mirabilis is a common uropathogen responsible for urinary tract infections (UTIs). The emrA gene encodes the EmrA protein, which is a critical component of the EmrAB-TolC multidrug efflux pump. In addition to its established role in antibiotic resistance, emerging evidence indicates that EmrA is also implicated in bacterial stress adaptation and virulence-associated processes. Nevertheless, its specific functions in the pathogenesis of P. mirabilis remain unclear.
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