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Huangui Zhang on Muck Rack

Huangui Zhang

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Articles

The identification of genes related to METTL14 inhibition in radiation-induced hepatocyte death based on bioinformatics analysis

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By Li Qu, Jiayi Wu, Huazhong Wang, Jiang Yu, Yuzhen He, Yiteng Ding, Wenjun Yin, Sijian Liu, Kewei Tan, Huangui Zhang
| Nature Verified
Abstract Radiation-Induced Liver Disease (RILD) is a major dose-limiting complication in radiotherapy for hepatocellular carcinoma, yet its molecular mechanisms remain incompletely understood compared to radiation injury in other organs. Programmed cell death (PCD) pathways like apoptosis, pyroptosis, and ferroptosis are crucial in RILD development. The m6A modification enzyme METTL14 is implicated in driving these PCD pathways, but its role in radiation-induced hepatocyte injury was unknown.
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