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Huanze Weng on Muck Rack

Huanze Weng

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Branched-chain amino acids contribute to diabetic kidney disease progression via PKM2-mediated podocyte metabolic reprogramming and apoptosis - Nature Communications

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By Huishou Zhao, Shan Wang Verified, Wenqi Tian, Jinyang Xu, Lu Peng, Xiaoming Xu, Cheng Wang, Di Wang, Pingping Xing, Fuyang Zhang, Shiyu Liu, Xiuhong Dou, Huanze Weng
| Nature Verified
Abstract Approximately 30-40% of patients with diabetes develop diabetic kidney disease (DKD). Identifying decisive factors for DKD initiation is crucial. Here, we observed that glomerular podocytes in male and female patients with DKD and db/db mice specifically displayed BCAA catabolic defects.
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