Huarong Bai

1. Introduction Rabies is a fatal disease caused by the rabies virus (RABV). RABV invades the host’s central nervous system and causes pathological changes. Once the virus takes effect and the symptoms appear, it cannot be eliminated by the immune system or any drugs, and the fatality rate is nearly 100%. Traditional rabies vaccines have been a cornerstone in the prevention of this deadly disease for decades.

Abstract Rabies is a preventable zoonotic disease caused by the rabies virus (RABV) with a high mortality rate. Most vaccines on the market or under development have issues such as a low single-dose neutralization titer, complex processes, and high costs. During the COVID-19 pandemic, the successful development of mRNA vaccines has opened up a new avenue for preventive vaccines. As a new technology, mRNA has higher scalability.