Huck Hui Ng on Muck Rack

Huck Hui Ng

As seen in: Nature, Cell Reports Medicine
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Articles

Spatial architecture of autism pathogenesis reveals mosaic structural disarray during early development

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By Li Lin, Tzuen Yih Saw, Nigel Chou, Vipul Singhal, Zheng Li, Mike Huang, Huck Hui Ng, Chiea Chuen Khor, Hwee Kuan, Kok Hao Chen, Shyam Prabhakar, Jinyue Liu, Jing Eugene Kwa
| Nature Verified
Abstract Autism spectrum disorder (ASD) has been associated with diverse genetic factors and molecular changes. Yet, how pathophysiology emerges during development and contributes to clinical heterogeneity remains unclear. Here we use spatial and single-cell transcriptomics of genetically diverse patient-derived organoids of the prenatal cortex to map the spatial architecture of ASD pathogenesis.
Open in Who Shared Issue with article?
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By Yixin Xiao, Paul Kim, Alfred Xuyang Sun, Qiang Yuan, Shawn Tan, Danlei Wang, Levena Sani, Hoang-Dai Tran, Yong Seng Chiew, Kea Joo Lee, Yi-Chun Yen, Huck Hui Ng, Hyunsoo Shawn Je
| secure.jbs.elsevierhealth.com
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