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Mobilization of γδ T Cells and IL-10 Production at the Acute Phase of Hepatitis E Virus Infection in Cytomegalovirus Carriers
Hugo Barragué, Jessica Fontaine, Florence Abravanel, Emilie Mauré, Jean-Marie Péron, Laurent Alric, Martine Dubois, Jacques Izopet and Eric Champagne J Immunol March 1, 2021, 206 (5) 1027-1038; DOI: https://doi.org/10.4049/jimmunol.2000187 Key Points Non-Vδ2 γδ T cells expand at the acute phase of HEV infection in HCMV carriers. HEV promotes IL-10 production and suppressive activity in Th1-type γδ T cells. Serum IL-10 is specifically elevated in HEV-infected HCMV carriers.
Mobilization of γδ T Cells and IL-10 Production at the Acute Phase of Hepatitis E Virus Infection in Cytomegalovirus Carriers
Hugo Barragué, Jessica Fontaine, Florence Abravanel, Emilie Mauré, Jean-Marie Péron, Laurent Alric, Martine Dubois, Jacques Izopet and Eric Champagne J Immunol January 22, 2021, ji2000187; DOI: https://doi.org/10.4049/jimmunol.2000187 Key Points Non-Vδ2 γδ T cells expand at the acute phase of HEV infection in HCMV carriers. HEV promotes IL-10 production and suppressive activity in Th1-type γδ T cells. Serum IL-10 is specifically elevated in HEV-infected HCMV carriers.
Aminobisphosphonates reveal a selective anti-viral potential of Vγ9Vδ2 T cells
Vγ9Vδ2 cells are activated by stressed cells producing endogenous phosphoantigens (PAgs) following tumoral transformation or treatment with aminobisphosphonates (ABP) such as zoledronate (Zol). Alternatively they respond to exogenous PAgs produced by bacteria. Their potential interest in viral infections is not well established. We analyzed in vitro their activation and activity against HCMV-infected cells.
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