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Hugo GJ Damstra

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Articles

Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells

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By Peter Jan Hooikaas, Maud Martin, Hugo GJ Damstra, Oane J Gros
| eLife
Abstract When a T cell and an antigen-presenting cell form an immunological synapse, rapid dynein-driven translocation of the centrosome toward the contact site leads to reorganization of microtubules and associated organelles. Currently, little is known about how the regulation of microtubule dynamics contributes to this process. Here, we show that the knockout of KIF21B, a kinesin-4 linked to autoimmune disorders, causes microtubule overgrowth and perturbs centrosome translocation.
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