Hui Xian Poh

Conclusions and future directions Understanding the exact roles of the individual m6A writer complex proteins will require high-resolution structural studies, such as cryo-EM, of the writer complex, in the presence or absence of possible regulatory modifications. Cryo-EM may provide insights into the assembly and interactions within the m6A writer complex, revealing novel details about its dynamics.

1PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Brunei 2School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India 3Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Saveetha University, Chennai, India 4Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, Australia 5School of Pharmaceutical Sciences, Lovely...

METTL3 knockout cell lines are generally not viable Several METTL3 knockout cell lines have been reported despite the fact that METTL3 is thought to be an essential gene. Mettl3 knockout is embryonic lethal in mice at E5.5 before cell specification occurs [5], and CRISPR screens have indicated that METTL3 is an essential gene in specific cell lines that were tested [7,42].