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Effects of local heat on metabolic health, frailty risk, and exercise adaptations in pre-diabetic older adults: Protocol for the Heat and Exercise in Aging as Therapy (HEAT) clinical trial
Loading metrics Open Access Study Protocol Citation: Luk H-Y, Appell CR, Zhang F, Blinch J, Nair KS, Shen C-L, et al. (2026) Effects of local heat on metabolic health, frailty risk, and exercise adaptations in pre-diabetic older adults: Protocol for the Heat and Exercise in Aging as Therapy (HEAT) clinical trial. PLoS One 21(6): e0351577. https://doi.org/10.1371/journal.pone.0351577 Editor: Jeremy B.
Passive dehydration increases oxidative stress and mTOR signalling pathway activation in young men following resistance exercise
Supporting Information Filename Description tjp16806-sup-0001-PeerReview.pdf1.4 MB Peer Review History References , , , , , & (2019). Skeletal muscle: A significant novel neurohypophyseal hormone-secreting organ. Frontiers in Physiology, 9, 1885. , , , , , , , , , , , , , & (2010). ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proceedings of the National Academy of Sciences of the United States of America, 107(9), 4153–4158. Anon. (2005).
Resistance exercise‐induced circulating factors influence the damaged skeletal muscle proteome in a sex‐dependent manner
1 INTRODUCTION Recovery from muscle damage requires the orchestration of various physiological processes which can be altered by circulating factors (e.g., cytokines, growth factors, etc.) (Karalaki et al., 2009) and intracellular signaling (e.g., autophagy) (Chen et al., 2022). Some of these circulating factors and cell signals are responsive to exercise and can differ based on sex, age, etc. (Kraemer et al., 1999; Luk et al., 2022; Luk, Appell, et al., 2021; Pierce et al., 2020).
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