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Huiye Wang on Muck Rack

Huiye Wang

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Articles

TLR9-activating cholesterol azetidine derivative–assisted therapeutic vaccines for cancer immunotherapy

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By Zhen He, Yudai Sato, Sophie R Shoemaker, Jun Wang, Huiye Wang
| Science Magazine Verified
Abstract Therapeutic cancer vaccines show great promise for de novo induction of antigen-specific T cell responses against tumors. However, weak coordination between innate immune activation and antigen delivery remains a major obstacle to vaccine efficacy. Here, we present a cholesterol azetidine derivative–assisted polymeric carrier, Aze-Chol NP, which stimulates innate immunity and primes tumor-specific CD8+ T cell responses.
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