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Joint analysis of WES and RNA‐Seq identify signature genes related to metastasis in prostate cancer
Transcriptomic architectures of PCa and metastasis We employed PCA and found the samples were clustered into three groups except for two outliers, PC2 and M_PC4 (Figure 2A), which were then removed for subsequent analysis. DEGs (adjusted p < 0.05 and |log2FC| > 1) were then identified using the DESeq2 package, with a total of 4005, 2925, and 102 yielded from each comparison (Data ).
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